G. Brian Golding, Ph.D.



Biomonitoring 2.0 – Steering Committee and Research Collaborator

Professor – McMaster University

Dr. Golding is employed as a CRC Professor at McMaster University. He is currently the head of the Computational Biology laboratory. His research interests are in the areas of molecular evolution, bioinformatics, and sequence analysis. Dr. Golding’s group seeks to understand how the processes of evolution act to cause the changes observed
between molecules, between genes, and between genomes. He makes use of computer-based analysis, statistical analysis, and mathematical models to answer broad questions about the molecular biology of all organisms. As a part of the Biomonitoring 2.0 project, Dr. Golding is investigating DNA sequence identification and evolution using new bioinformatic approaches.


B.Sc. – Dalhousie University (1976)

Ph.D. – University of Alberta (1982)


Select Publications

Lou M, Golding GB. 2012. The effect of sampling from subdivided populations on species identification with DNA barcodes using a Bayesian statistical approach. Molecular Phylogenetics and Evolution 65(2): 765-773.

Porter T, Golding GB. 2012. Factors that affect large subunit ribosomal DNA amplicon sequencing studies of fungal communities: classification method primer choice and error. PLoS one 7(4): e35749.

Huang YF, Golding GB. 2012. Inferring sequence regions under functional divergence in duplicate genes. Bioinformatics 28(2): 176-183.

Haerty W, Golding GB. 2011. Increased polymorphism near low-complexity sequences across the genomes of Plasmodium falciparum isolates. Genome Biology and Evolution 3: 539-550.

Porter T, Golding GB. 2011. Are similarity or phylogenetic-based methods more appropriate for classifying internal transcribed spacer (ITS) metagenomic amplicons? New Phytologist 192: 775-782.

Hao W, Golding GB. 2010. Inferring bacterial genome flux while considering truncated genes. Genetics 186(1): 411-426.

Lou M, Golding GB. 2010. Assigning sequences to species in the absence of large interspecific differences. Molecular Phylogenetics and Evolution 56(1): 187-194.

Haerty W, Golding GB. 2010. Genome-wide evidence for selection acting on single amino acid repeats. Genome Research 20(6): 755-760.


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